The best Side of akorn codeine

The best Side of akorn codeine

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Lifestyle-Threatening Respiratory Despair Notify people of the chance of lifetime-threatening respiratory despair, including info that the risk is greatest when starting off promethazine HCl and codeine phosphate oral Answer Which it can happen even at advisable dosages [see Warnings and Precautions (five.

g., amiodarone, quinidine) may well cause a rise in codeine plasma concentrations and also a minimize in Energetic metabolite morphine plasma focus which could lead to an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.

Promethazine is very well absorbed in the gastrointestinal tract. Scientific effects are obvious inside of 20 minutes soon after oral administration and usually very last four to six several hours, Even though they may persist as long as twelve hrs.

Codeine is known to become significantly excreted from the kidney, and the chance of adverse reactions to this drug can be greater in individuals with impaired renal operate.

Evaluate each affected person’s chance just before prescribing promethazine HCl and codeine phosphate oral Resolution, prescribe promethazine HCl and codeine phosphate oral Alternative with the shortest duration that is in line with personal affected individual treatment method objectives, check all people on a regular basis for the development of addition or abuse, and refill only after reevaluation of the need for continued treatment. [see Warnings and Precautions (5.one)]

Promethazine HCl and codeine phosphate oral Answer needs to be used click here with warning in patients with impairment of hepatic purpose, and people need to be monitored closely for respiratory despair, sedation, and hypotension.

Make certain accuracy when prescribing, dispensing, and administering promethazine HCl and codeine phosphate oral Resolution. Dosing glitches may lead to accidental overdose and Dying.

5.seven Dangers of Accidental Overdose and Loss of life because of Medication Errors Dosing problems can lead to accidental overdose and Dying. To cut back the risk of overdose and respiratory despair, make sure the dose of promethazine HCl and codeine phosphate oral Remedy is communicated clearly and dispensed correctly [see Dosage and Administration (2.one)]. Suggest sufferers to constantly use an correct milliliter measuring product when measuring and administering promethazine HCl and codeine phosphate oral Resolution.

Due to inconsistencies amongst the drug labels on DailyMed and also the capsule visuals provided by RxImage, we not Exhibit the RxImage capsule photos linked to drug labels.

Stimulation could possibly be obvious, especially in small children and geriatric sufferers. Convulsions may perhaps seldom come about. A paradoxical response continues to be claimed in kids getting solitary doses of 75 mg to one hundred twenty five mg orally, characterized by hyperexcitability and nightmares.

Revealed experiments with codeine have claimed inconsistent findings and possess critical methodological constraints (see Info). There are reports of respiratory despair when codeine is utilized throughout labor and delivery (see Scientific Issues).

Stay clear of the use of promethazine HCl and codeine phosphate oral Remedy in patients who are having inhibitors of CYP2D6.

are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and could potentially cause critical Unwanted effects in your little one which include elevated sleepiness, respiration complications (respiratory despair), and death. It's not at all recognised if promethazine can move into your breast milk.

Postmarketing cases of respiratory melancholy, which includes fatalities are already reported with utilization of promethazine in pediatric people.